Topic: Research News
Researchers at the University of Pennsylvania used artificial intelligence to analyze over 400,000 Reddit posts about semaglutide and tirzepatide. They found several side effects that patients discussed online but not in clinical trials.
Popular weight loss and diabetes medications have changed how we treat obesity and blood sugar control. Now, scientists are using artificial intelligence to help uncover side effects that patients discuss online but aren't always reflected in clinical trials or official drug documentation.
Researchers at the University of Pennsylvania analyzed over 400,000 Reddit posts written by nearly 70,000 users over five years. They found several commonly discussed symptoms, including some that may deserve closer scientific attention, such as menstrual irregularities and temperature-related complaints like chills and hot flashes.
The study's senior author, Sharath Chandra Guntuku, says the findings highlight the importance of online discussions in uncovering side effects.
Implications
Researchers at the University of Pennsylvania used artificial intelligence to analyze over 400,000 Reddit posts about semaglutide and tirzepatide. They found several side effects that patients discussed online but not in clinical trials.
Source: https://www.sciencedaily.com/releases/2026/05/260523103914.htm
Journal Reference:
- Neil K. R. Sehgal, Jena Shaw Tronieri, Lyle Ungar, Sharath Chandra Guntuku. Self-reported side effects of semaglutide and tirzepatide in online communities. Nature Health, 2026; DOI: 10.1038/s44360-026-00108-y
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