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Coffee's Surprising Effect on Gut and Brain

Published on June 22, 2026, 1:12 p.m.
Coffee's Surprising Effect on Gut and Brain

Topic: Health

Scientists discovered how coffee affects our gut microbiome and mood. Regularly drinking coffee can shape our gut bacteria and influence stress levels.

Researchers at APC Microbiome Ireland, a leading research center at University College Cork, have made a significant breakthrough in understanding the benefits of coffee for our bodies. For the first time, scientists have closely examined how coffee interacts with the gut-brain axis, the communication network that links our digestive system and brain. The findings show that regularly drinking both caffeinated and decaffeinated coffee can shape our gut microbiome and influence our mood and stress levels.

Coffee has long been associated with digestive and mental health benefits, but the biological reasons behind these effects have not been fully understood. This study focused on how coffee impacts the microbiota-gut-brain axis using a wide range of biological and psychological measurements.

To explore this, researchers compared 31 regular coffee drinkers with 31 people who do not drink coffee. Participants completed psychological assessments, tracked their diet and caffeine intake, and provided stool and urine samples so scientists could analyze changes in gut bacteria and emotional state.

Why It Matters

This study matters because it shows that coffee can have a positive impact on our mental health and well-being. As students, we often rely on coffee to stay focused and alert during long study sessions or exams. Now, we know that this habit may also be beneficial for our gut health and mood.

Key Facts

  • The study found that regularly drinking both caffeinated and decaffeinated coffee can shape the gut microbiome and influence mood and stress levels.
  • Coffee drinkers who stopped consuming coffee for two weeks showed clear shifts in their metabolites produced by gut microbes, setting them apart from non-coffee drinkers.
  • Levels of 'Eggertella sp' and 'Cryptobacterium curtum' were higher among those who regularly consumed coffee.
  • Decaffeinated coffee was found to improve learning and memory, while caffeinated coffee showed distinct advantages in reducing anxiety and improving attention and alertness.
  • The study suggests that compounds other than caffeine, such as polyphenols, may be responsible for certain cognitive benefits.

Key Terms

Gut-brain axis
The communication network between our digestive system and brain

Implications

This study matters because it shows that coffee can have a positive impact on our mental health and well-being. As students, we often rely on coffee to stay focused and alert during long study sessions or exams. Now, we know that this habit may also be beneficial for our gut health and mood.


Source: https://www.sciencedaily.com/releases/2026/05/260502233911.htm

Journal Reference:

  1. Serena Boscaini, Thomaz F. S. Bastiaanssen, Gerard M. Moloney, Federica Bergamo, Laila Zeraik, Caroline O’Leary, Aimone Ferri, Maha Irfan, Maaike van der Rhee, Thaïs I. F. Lindemann, Elizabeth Schneider, Arthi Chinna Meyyappan, Kirsten Berding Harold, Caitríona M. Long-Smith, Carina Carbia, Kenneth J. O’Riordan, José Fernando Rinaldi de Alvarenga, Nicole Tosi, Daniele Del Rio, Alice Rosi, Letizia Bresciani, Pedro Mena, Gerard Clarke, John F. Cryan. Habitual coffee intake shapes the gut microbiome and modifies host physiology and cognition. Nature Communications, 2026; 17 (1) DOI: 10.1038/s41467-026-71264-8

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