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New Antiviral Drug Stops Measles Before It Spreads

Mayur Tembhare
  1. Scientists at Georgia State University developed a new oral antiviral drug called GHP-88310 that can prevent measles from spreading.

  2. The drug was tested on ferrets and blocked both close contact and airborne transmission of the virus.

  3. GHP-88310 also reduced the length of time infected animals remained capable of transmitting the virus.

  4. The researchers are now preparing GHP-88310 for formal clinical trials to test its safety and effectiveness in humans.

New Antiviral Drug Stops Measles Before It Spreads

Topic: Health

Scientists at Georgia State University developed a new oral antiviral drug that can prevent measles from spreading. The drug, called GHP-88310, was tested on ferrets and blocked both close contact and airborne transmission of the virus.

Researchers at Georgia State University have made an important discovery in the fight against measles. They developed a new oral antiviral drug called GHP-88310 that can prevent the spread of the virus.

The team tested this drug on ferrets, which are often used as models for human diseases. The ferrets were infected with a measles-like virus and then given the new drug. The results showed that the drug was very effective in blocking both close contact and airborne transmission of the virus.

But that's not all - when the drug was given to animals that were already infected, it also reduced the length of time they remained capable of transmitting the virus. This is a big deal because it could help prevent outbreaks and reduce the number of people who get sick.

The researchers are now preparing GHP-88310 for formal clinical trials, which means testing it on humans to see if it's safe and effective. If it works as well in humans as it did in ferrets, it could be a game-changer in the fight against measles.

Why It Matters

Measles is still a major problem in many parts of the world, including India. This new antiviral drug could help prevent outbreaks and save lives.

Key Facts

  • Scientists at Georgia State University developed a new oral antiviral drug called GHP-88310 that can prevent measles from spreading.
  • The drug was tested on ferrets and blocked both close contact and airborne transmission of the virus.
  • GHP-88310 also reduced the length of time infected animals remained capable of transmitting the virus.
  • The researchers are now preparing GHP-88310 for formal clinical trials to test its safety and effectiveness in humans.
  • Measles has reemerged in North America, causing thousands of infections and several deaths.

Key Terms

viral polymerase
An enzyme that the virus needs to reproduce
prophylactic
Given before or after exposure to prevent infection

Implications

Measles is still a major problem in many parts of the world, including India. This new antiviral drug could help prevent outbreaks and save lives.

Source: https://www.sciencedaily.com/releases/2026/07/260724061431.htm

Journal reference:

  1. Carolin M. Lieber, Josef D. Wolf, Claire E. Ruckel, Lauren A. Harrison, Richard K. Plemper. Antiviral GHP-88310 blocks contact-mediated and airborne transmission in a ferret model of measles-like disease. Nature Microbiology, 2026; DOI: 10.1038/s41564-026-02419-y
  2. Carolin M. Lieber, Josef D. Wolf, Mugunthan Govindarajan, Jeong-Joong Yoon, Zachary M. Sticher, Claire E. Ruckel, Alexander I. Leach, Lauren A. Harrison, Dariia Vyshenska, Amalia A. Cruz, Meghan K. Andrews, Rebecca E. Krueger, Robert M. Cox, George R. Painter, Alexander L. Greninger, Michael G. Natchus, Richard K. Plemper. Developmental candidate GHP-88310/EIDD-3608 with high tolerability and oral efficacy in measles and respiratory paramyxovirus models. Science Advances, 2026; 12 (21) DOI: 10.1126/sciadv.aef1594

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