Topic: Research News
Scientists have developed a new medicine that helps people with obesity and type 2 diabetes lose weight and control their blood sugar levels. The drug works by targeting specific cells in the body.
Researchers at Helmholtz Munich, led by metabolism expert Prof Timo D. Müller, have created a new strategy to treat obesity and type 2 diabetes. Their approach uses a specially designed hybrid molecule that takes advantage of the well-known GLP-1/GIP signalling pathway as an entry point into cells. Once inside, it delivers an additional metabolic compound directly where it is needed.
In laboratory tests, mice treated with this compound ate less food, lost more weight, and showed better blood-glucose control than those given standard comparison treatments. The findings were published in the journal Nature.
The team designed what they call an
Implications
Scientists have developed a new medicine that helps people with obesity and type 2 diabetes lose weight and control their blood sugar levels. The drug works by targeting specific cells in the body.
Source: https://www.sciencedaily.com/releases/2026/05/260506225428.htm
Journal Reference:
- Daniela Liskiewicz, Aaron Novikoff, Ahmed Khalil, Seun Akindehin, Jonathan E. Campbell, Pietra Candela, Russell L. Castelino, Callum Coupland, Maxime Culot, W. Scott Dodson, Jonathan D. Douros, Hannes Embring, Annette Feuchtinger, Brian Finan, Cristina Garcia-Caceres, Xiao-Bing Gao, Fabien Gosselet, Gerald Grandl, Robert M. Gutgesell, Daniel T. Haas, Martin Jastroch, Ezgi Karaoglu, Pamela Kakimoto, Anna Cristina Kaltenbach, Michaela Keuper, Christine M. Kusminski, Danielle C. Leander, Arkadiusz Liskiewicz, Xue Liu, Gandhari Maity-Kumar, Sara Martinez Martinez, Stephanie A. Mowery, Ruben Nogueiras, Marshall Paisley, Diego Perez-Tilve, Patricia S. S. Petersen, Paul T. Pfluger, Sneha Prakash, Sabine Steffens, Alberto Cebrian-Serrano, Monica Tost, Jordan Wean, Christian Weber, Junichi Yoshida, Zachary Gerhart-Hines, Tamas L. Horvath, Philipp E. Scherer, Randy J. Seeley, Richard D. DiMarchi, Matthias H. Tschöp, Natalie Krahmer, Patrick J. Knerr, Timo D. Müller. GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice. Nature, 2026; DOI: 10.1038/s41586-026-10427-5
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