Topic: Health
Scientists found that a medicine called sulthiame can help people with sleep apnea breathe more easily at night. This is good news for those who struggle to use breathing masks.
Sleep apnea happens when the airway collapses during sleep, causing breathing pauses and low oxygen levels. Many people find it hard to use breathing masks that keep their airways open. Researchers from the University of Gothenburg have found a new way to help these patients. They tested a medicine called sulthiame on 298 people with moderate to severe sleep apnea. The results showed that those who took higher doses of sulthiame had up to 47% fewer breathing interruptions during sleep compared to those who took a placebo. This medicine may become a new treatment option for patients who struggle to use breathing masks.
The study was led by Jan Hedner, a senior professor of pulmonary medicine at the Sahlgrenska Academy, University of Gothenburg. He says that the results are a breakthrough and that they now want to conduct larger studies to see if this treatment is safe and effective for more people.
Sulthiame appears to work by stabilizing the body's control of breathing and increasing respiratory drive. This helps lower the likelihood that the upper airway will collapse during sleep, which is the main cause of obstructive sleep apnea.
Why It Matters
This new treatment option could help many people in India who struggle with sleep apnea. It may also reduce the risk of serious health problems like high blood pressure and cardiovascular disease.
Key Facts
- The study tested a medicine called sulthiame on 298 people with moderate to severe sleep apnea.
- Those who took higher doses of sulthiame had up to 47% fewer breathing interruptions during sleep compared to those who took a placebo.
- Sulthiame appears to work by stabilizing the body's control of breathing and increasing respiratory drive.
- The study was led by Jan Hedner, a senior professor of pulmonary medicine at the Sahlgrenska Academy, University of Gothenburg.
- The results show that sleep apnea can indeed be influenced pharmacologically.
Key Terms
- Obstructive Sleep Apnea
- A condition where the airway collapses during sleep, causing breathing pauses and low oxygen levels
Implications
This new treatment option could help many people in India who struggle with sleep apnea. It may also reduce the risk of serious health problems like high blood pressure and cardiovascular disease.
Source: https://www.sciencedaily.com/releases/2026/03/260311004816.htm
Journal Reference:
- Winfried Randerath, Ludger Grote, Kaj Stenlöf, Ingo Fietze, Julia Chevts, Erik Buntinx, Javier Albares, Katrin Kuhn, Corinna Hansen, Andreas Völp, Jan Hedner, Dries Testelmans, Jean-Benoit Martinot, Farhad Baharloo, Benny Gimbada Mwenge, Erik Buntinx, Pierre Philip, Jean Louis Pepin, Frederic Gagnadoux, Maxime Patout, Maria Fernanda Troncoso Acevedo, Alejandro Iranzo de Riquer, Francisco Martinez-Orozco, Francisco Javier Puertas Cuesta, Ainhoa Alvarez Ruiz de Larrinaga, Francisco Javier Albares Tendero, Christian Viniol, Winfried Randerath, Heike Benes, Ingo Fietze, Geert Mayer, Katrin Gade, Christian Deckert, Peter Heymer, Frank Kaessner, Julia Chevts, Henning Candler, Zbysek Pavelek, Samuel Genzor. Sultiame once per day in obstructive sleep apnoea (FLOW): a multicentre, randomised, double-blind, placebo-controlled, dose-finding, phase 2 trial. The Lancet, 2025; 406 (10514): 1983 DOI: 10.1016/S0140-6736(25)01196-1
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