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Omega-3 Fish Oil Supplements Can Have Unintended Consequences

Mayur Tembhare
  1. million adults in the United States take fish oil supplements.

  2. Omega-3 fatty acids like EPA and DHA are found in fish oil supplements.

  3. The study found that fish oil supplements increased colon tumors in mice exposed to chemicals that trigger inflammation and speed up tumor growth.

  4. ALOX15 is a key enzyme that plays a crucial role in how omega-3 fatty acids affect our bodies.

Omega-3 Fish Oil Supplements Can Have Unintended Consequences

Topic: Health

Researchers found that omega-3 fish oil supplements may not be effective for everyone. A key enzyme called ALOX15 plays a crucial role in how these supplements affect our bodies.

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Key Facts

  • 19 million adults in the United States take fish oil supplements.
  • Omega-3 fatty acids like EPA and DHA are found in fish oil supplements.
  • The study found that fish oil supplements increased colon tumors in mice exposed to chemicals that trigger inflammation and speed up tumor growth.
  • ALOX15 is a key enzyme that plays a crucial role in how omega-3 fatty acids affect our bodies.
  • People with colon polyps who do not have active ALOX15 may not receive the same protective benefits from omega-3 supplements.

Key Terms

ALOX15
A key enzyme that plays a crucial role in how omega-3 fatty acids affect our bodies

Implications

Researchers found that omega-3 fish oil supplements may not be effective for everyone. A key enzyme called ALOX15 plays a crucial role in how these supplements affect our bodies.

Source: https://www.sciencedaily.com/releases/2026/02/260212234216.htm

Journal reference:

  1. Xiangsheng Zuo, Yoshiyuki Kiyasu, Yi Liu, Yasunori Deguchi, Fuyao Liu, Micheline Moussalli, Lin Tan, Bo Wei, Daoyan Wei, Peiying Yang, Imad Shureiqi. Colorectal 15-Lipoxygenase-1 as a Host Factor Determining the Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Colorectal Tumorigenesis in Mice. Cellular and Molecular Gastroenterology and Hepatology, 2025; 19 (12): 101607 DOI: 10.1016/j.jcmgh.2025.101607

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