Topic: Research News
Researchers at UC San Francisco found that people with multiple sclerosis have higher levels of certain immune cells that respond to Epstein-Barr virus. This suggests the virus may contribute to the disease.
Multiple sclerosis is a long-term autoimmune condition that affects nearly one million people in the United States. Scientists have known for years that Epstein-Barr virus (EBV) is closely linked to MS, but they didn't know how it contributed to the disease.
A team of researchers at UC San Francisco has made new discoveries that may help explain this connection. They found that people with MS have higher levels of certain immune cells called CD8+
Implications
Researchers at UC San Francisco found that people with multiple sclerosis have higher levels of certain immune cells that respond to Epstein-Barr virus. This suggests the virus may contribute to the disease.
Source: https://www.sciencedaily.com/releases/2026/02/260206232245.htm
Journal Reference:
- Fumie Hayashi, Kristen Mittl, Ravi Dandekar, Josiah Gerdts, Ebtesam Hassan, Ryan D. Schubert, Lindsay Oshiro, Rita Loudermilk, Ariele Greenfield, Danillo G. Augusto, Gregory Havton, Shriya Anumarlu, Arhan Surapaneni, Akshaya Ramesh, Edwina Tran, Kanishka Koshal, Kerry Kizer, Joanna Dreux, Alaina K. Cagalingan, Florian Schustek, Lena Flood, Tamson Moore, Lisa L. Kirkemo, Isabelle J. Fisher, Tiffany Cooper, Meagan Harms, Refujia Gomez, Ahmed Abdelhak, Sergio Baranzini, Riley Bove, Stacy Caillier, Richard Cuneo, Jeffrey Gelfand, Ari Green, Joanne Guo, Sasha Gupta, Harkee Halait, Roland G. Henry, Jill A. Hollenbach, Jorge R. Oksenberg, Nico Papinutto, Samuel Pleasure, Adam Renschen, Simone Sacco, Adam Santaniello, Anna Sindalovsky, Claire D. Clelland, Leah Sibener, Bruce A. C. Cree, Stephen L. Hauser, Jill A. Hollenbach, Marvin Gee, Michael R. Wilson, Scott S. Zamvil, Joseph J. Sabatino. Antigen specificity of clonally enriched CD8 T cells in multiple sclerosis. Nature Immunology, 2026; DOI: 10.1038/s41590-025-02412-3
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