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Sea Squirts May Hold Secret to Reversing Signs of Aging

Mayur Tembhare
  1. Scientists from Xi'an Jiaotong-Liverpool University and Stanford University found that dietary supplements containing compounds from sea squirts can reverse signs of aging in mice.

  2. The study suggests that plasmalogens, a type of lipid (fat molecule), may help restore connections between brain cells and improve cognitive function.

  3. Sea squirts contain high levels of plasmalogens, which occur naturally throughout the human body and are especially abundant in the brain, heart, and immune cells.

  4. The study provides the first detailed look at how plasmalogens may influence the aging brain.

Sea Squirts May Hold Secret to Reversing Signs of Aging

Topic: Health

Scientists from Xi'an Jiaotong-Liverpool University and Stanford University found that dietary supplements containing compounds from sea squirts can reverse signs of aging in mice. The study suggests that these compounds, called plasmalogens, may help restore connections between brain cells and improve cognitive function.

Aging is a natural process that affects us all. As we grow older, our bodies start to show signs of wear and tear, from gray hair and wrinkles to lapses in memory. But what if there was a way to reverse these changes? A team of scientists from Xi'an Jiaotong-Liverpool University and Stanford University may have found the answer in sea squirts.

Sea squirts are marine animals that are eaten in parts of Asia, including Korea and Japan. They contain high levels of compounds called plasmalogens, which are a type of lipid (fat molecule) that forms an important part of cell membranes. Plasmalogens occur naturally throughout the human body and are especially abundant in the brain, heart, and immune cells.

The researchers added plasmalogens to the diets of aged mice and examined how the supplements affected both their behavior and their bodies. The results were striking: the treated mice showed substantial improvements in learning and displayed visible physical changes as well. They even grew new black hair that was thicker and glossier than aged mice not fed the supplement.

The study provides the first detailed look at how plasmalogens may influence the aging brain. The researchers found that mice given plasmalogens had more synapses, which are the tiny junctions through which nerve cells communicate. They also found that these synapses appeared to be in better condition than those in untreated aged mice.

Synapses are highly adaptable early in life, but with age, they can become less numerous and less effective. This deterioration is associated with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. The study suggests that restoring plasmalogens may help protect the brain from some of these changes.

Why It Matters

This research has important implications for India, where the population is aging rapidly. As people live longer, they are more likely to develop age-related diseases such as Alzheimer's and Parkinson's. If sea squirts can be used to reverse signs of aging, it could lead to new treatments and therapies for these conditions.

Key Facts

  • Scientists from Xi'an Jiaotong-Liverpool University and Stanford University found that dietary supplements containing compounds from sea squirts can reverse signs of aging in mice.
  • The study suggests that plasmalogens, a type of lipid (fat molecule), may help restore connections between brain cells and improve cognitive function.
  • Sea squirts contain high levels of plasmalogens, which occur naturally throughout the human body and are especially abundant in the brain, heart, and immune cells.
  • The study provides the first detailed look at how plasmalogens may influence the aging brain.
  • The researchers found that mice given plasmalogens had more synapses and better-conditioned synapses than untreated aged mice.

Key Terms

Plasmalogens
A type of lipid (fat molecule) that forms an important part of cell membranes.
Synapses
The tiny junctions through which nerve cells communicate.

Implications

This research has important implications for India, where the population is aging rapidly. As people live longer, they are more likely to develop age-related diseases such as Alzheimer's and Parkinson's. If sea squirts can be used to reverse signs of aging, it could lead to new treatments and therapies for these conditions.

Source: https://www.sciencedaily.com/releases/2026/09/260902234518.htm

Journal reference:

  1. Jinxin Gu, Lixue Chen, Ran Sun, Jie-Li Wang, Juntao Wang, Yingjun Lin, Shuwen Lei, Yang Zhang, Dan Lv, Faqin Jiang, Yuru Deng, James P. Collman, Lei Fu. Plasmalogens Eliminate Aging-Associated Synaptic Defects and Microglia-Mediated Neuroinflammation in Mice. Frontiers in Molecular Biosciences, 2022; 9 DOI: 10.3389/fmolb.2022.815320

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