Topic: Health
Scientists from the University of Barcelona found that two existing drugs can help reverse fatty liver disease. The study tested pemafibrate and telmisartan on animal models, showing promising results.
Fatty liver disease is a common condition worldwide, affecting about one in three adults. It occurs when excess fat builds up inside liver cells, leading to serious liver damage and an increased risk of heart and blood vessel disease. A recent study from the University of Barcelona suggests a potential breakthrough using medications that are already available.
Researchers found that two drugs, pemafibrate and telmisartan, were able to significantly reduce liver fat in animal models of this disease. Even more encouraging, using the two together appeared to not only improve liver health but also reduce related cardiovascular risks.
The study was led by Marta Alegret, a professor at the University of Barcelona's Faculty of Pharmacy and Food Sciences, and involved collaborations with several major research institutions.
Treatment options for fatty liver disease remain limited, making this potential new approach both safer and more effective than many experimental therapies.
Why It Matters
This breakthrough could lead to better treatment options for Indians affected by fatty liver disease. With India having a high prevalence of the condition, this finding has significant implications for public health in the country.
Key Facts
- Fatty liver disease is now the most common liver condition worldwide, affecting about one in three adults.
- The study found that pemafibrate and telmisartan can significantly reduce liver fat in animal models of fatty liver disease.
- Using the two drugs together appeared to not only improve liver health but also reduce related cardiovascular risks.
- Treatment options for fatty liver disease remain limited, making this potential new approach both safer and more effective than many experimental therapies.
Key Terms
- Metabolic dysfunction-associated steatotic liver disease
- A condition where excess fat builds up inside liver cells
Implications
This breakthrough could lead to better treatment options for Indians affected by fatty liver disease. With India having a high prevalence of the condition, this finding has significant implications for public health in the country.
Source: https://www.sciencedaily.com/releases/2026/04/260422003024.htm
Journal Reference:
- Roger Bentanachs, Patricia Ramírez-Carrasco, Bianca Braster, Anastasia Emmanouilidou, Endrina Mujica, Maite Rodrigo-Calvo, Cristina Rodríguez, Núria Roglans, Marcel den Hoed, Juan C. Laguna, Marta Alegret. Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD. Pharmacological Research, 2025; 218: 107860 DOI: 10.1016/j.phrs.2025.107860
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