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Young Adults May Already Have Hidden Artery Plaque

Mayur Tembhare
  1. The REACT study involved over 16,000 participants aged 18 to 70 from Denmark and Spain.

  2. .1% of young adults (18-30 years old) had hidden artery plaque.

  3. Atherosclerosis is the primary underlying cause of cardiovascular disease, which kills nearly 20 million people worldwide each year.

  4. The REACT study aims to transform primary cardiovascular prevention by identifying atherosclerosis early on through direct detection of plaque.

Young Adults May Already Have Hidden Artery Plaque

Topic: Health

A large international study found that nearly 6 in 10 young adults have hidden artery plaque. The study, called REACT, aimed to understand how silent atherosclerosis develops throughout adulthood. Researchers used advanced imaging to detect plaques in over 16,000 participants.

Atherosclerosis is the buildup of plaque inside arteries that can lead to heart attacks and strokes. For a long time, it was thought that this disease only affected older adults. However, a recent study suggests that young adults may already have hidden artery plaque.

The REACT study, led by Professor Henning Bundgaard from Denmark and Dr. Borja Ibáñez from Spain, involved over 16,000 participants aged 18 to 70. None of them had any symptoms or previous heart disease diagnosis. The researchers used advanced imaging techniques to detect atherosclerotic plaques in the participants' arteries.

The study found that nearly 6 in 10 young adults (57.1%) already have hidden artery plaque. This is much higher than previously thought, and it's concerning because having plaque doesn't necessarily mean you'll develop symptoms right away. However, cardiovascular disease kills nearly 20 million people worldwide each year.

The REACT study aims to transform primary cardiovascular prevention by identifying atherosclerosis early on. The researchers want to move from estimating the risk of heart disease based on traditional factors like cholesterol and blood pressure to directly detecting plaque through imaging. This approach can help guide preventive interventions and treatments more effectively.

Why It Matters

This study is important for Indian students because cardiovascular disease is a leading cause of death worldwide, including in India. Understanding how silent atherosclerosis develops can help us prevent heart attacks and strokes, which are major health concerns in our country.

Key Facts

  • The REACT study involved over 16,000 participants aged 18 to 70 from Denmark and Spain.
  • 57.1% of young adults (18-30 years old) had hidden artery plaque.
  • Atherosclerosis is the primary underlying cause of cardiovascular disease, which kills nearly 20 million people worldwide each year.
  • The REACT study aims to transform primary cardiovascular prevention by identifying atherosclerosis early on through direct detection of plaque.
  • The study was funded by the Novo Nordisk Foundation and published in The New England Journal of Medicine.

Key Terms

Atherosclerosis
The buildup of plaque inside arteries that can lead to heart attacks and strokes.
REACT
A large international study aimed at understanding how silent atherosclerosis develops throughout adulthood.

Implications

This study is important for Indian students because cardiovascular disease is a leading cause of death worldwide, including in India. Understanding how silent atherosclerosis develops can help us prevent heart attacks and strokes, which are major health concerns in our country.

Source: https://www.sciencedaily.com/releases/2026/09/260929053541.htm

Journal reference:

  1. Henning Bundgaard, Inés García-Lunar, Klaus F. Kofoed, Rasmus Hasselbalch, Carlos Nicolás Pérez-García, Joakim Bo Kunkel, Frederik Filip Stæger, Fátima Sánchez-Cabo, José J. Fuster, Virginia Mass, Javier Sánchez-González, Maja V. Kragh, Anna K. Ringgaard, Javier Valls-Monzó, Michael Huy Cuong Pham, Ana Devesa, Morten Sejer, Per Sigvardsen, Antonio Quesada, Charlotte Eberhard, Ana García-Álvarez, Lea Marie Pehrson, Álvaro Navarro-Guzmán, Simon Winther, Mathias Sørgaard, Marcos Gámez, Martin Lundsgaard, Cristina Pérez-Herreras, Ruth Frikke-Schmidt, Pedro L. Sánchez, Nikolaj Eldrup, Juan Torres-Macho, Morten Bøttcher, Valentin Fuster, Kasper K. Iversen, Borja Ibanez. Prevalence of Silent Atherosclerosis across Adult Life. New England Journal of Medicine, 2026; DOI: 10.1056/NEJMoa2609059

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