AI Helps Scientists Find Natural Weight Loss Molecule

Topic: Medicine

Stanford researchers used AI to discover a natural molecule that helps control appetite and weight. This molecule, called BRP, works differently than Ozempic but has fewer side effects.

Stanford Medicine researchers have found a naturally occurring molecule that may help people lose weight without the usual side effects of other weight loss medicines. The team used artificial intelligence to search through proteins in the body and found this new molecule, called BRP.

BRP works by targeting specific cells in the brain that control hunger and metabolism. Unlike Ozempic, which affects many parts of the body, BRP seems to only affect these cells. This could make it a more precise tool for controlling appetite and weight.

The researchers used AI to search through proteins called prohormones. Prohormones are inactive molecules that can be cut into smaller pieces called peptides. Some of these peptides act as hormones in the body, influencing metabolism and hunger. The team created an algorithm called Peptide Predictor to find the most promising prohormones.

The researchers focused on an enzyme called prohormone convertase 1/3, which cuts prohormones at specific sites. They used AI to search for other peptides that might be produced by this enzyme. After narrowing down their search, they found BRP and tested its effects in animal studies.

The team's discovery was published in the journal Nature on March 5, 2025. The lead author of the study is Laetitia Coassolo, PhD, and the senior author is Katrin Svensson, PhD. A company co-founded by Svensson plans to begin clinical trials of BRP in humans soon.

Why It Matters

This discovery could lead to new treatments for obesity and weight-related problems. It also shows how AI can help scientists find new medicines more quickly and efficiently.

Key Facts

• Stanford Medicine researchers used AI to discover a natural molecule called BRP that helps control appetite and weight.
• BRP works by targeting specific cells in the brain, unlike Ozempic which affects many parts of the body.
• The team created an algorithm called Peptide Predictor to find promising prohormones.
• The discovery was published in Nature on March 5, 2025.
• A company co-founded by Katrin Svensson plans to begin clinical trials of BRP in humans soon.

Key Terms

Prohormone

An inactive molecule that can be cut into smaller pieces called peptides.

Peptide

A small piece of a protein that acts as a hormone in the body.

Ozempic

A weight loss medicine that affects many parts of the body, including the brain and digestive system.

Implications

This discovery could lead to new treatments for obesity and weight-related problems. It also shows how AI can help scientists find new medicines more quickly and efficiently.